Holy F%$#ing Sh%$

We have a report that a a grad student synthesized dimethylmercury and possibly exposed themselves.

Dimethylmercury makes the Minimata Disease look like a trip to a pre-Amazon Whole Foods.

We had a weird story develop over the weekend here in the Cambridge area (and among organic chemists in general). I’m glad that I wasn’t trying to blog it as it happened, because it’s taken some turns!

This all started last Wednesday night, but most of us only heard something on Thursday when word came of an MIT chemistry building that was being closed off because of a report of someone who had been exposed to hazardous material. It became clear that said material was possibly dimethylmercury, which a graduate student had claimed to have synthesized, and who subsequently reported themselves to a local emergency room. And you can see why that caused a stir (but read on!)

Dimethylmercury is very, very bad news. It is obviously something I will not work with, but it’s never been the subject of a blog post here in that category because unfortunately there’s nothing lighthearted about the subject. Not after the death of Karen Wetterhahn in 1997. That story should be well known to chemists everywhere, but the short version is that Prof. Wetterhahn (at Dartmouth) was accidentally exposed in August of 1996 to a few drops of liquid dimethylmercury on her latex-gloved hand. What she didn’t know (and what none of us really knew) was that this compound rapidly penetrates such gloves, which meant that Wetterhahn was exposed to skin contact within seconds. Toxicologically, it is probably the worst of the organomercurys, which are of course a dangerously toxic group of compounds overall. Her precautions for handling the compound were the standard at the time, it should be noted.

Prof. Wetterhahn began to notice general symptoms within weeks. Early in 1997 she began to show neurological problems, and within weeks she had collapsed into a vegetative state. She was removed from life support in June. She had very high levels of mercury in her blood, and all attempts at chelation therapy to remove it were ineffective. That’s surely because it had spread throughout her body by the time the problem was recognized, but frankly no one can be sure if there were any measures that could have been effective enough after the initial exposure. This horrifying incident led to a complete re-evaluation of the use of dimethylmercury in synthetic and analytical chemistry, where among other things it had been the reference peak standard in mercury NMR experiments.

It appears that there was no exposure to anyone, and possibly that there was no actual synthesis of the ferociously toxic material, but someone was trying to make some.

Whoever they are should be blackballed from chemistry for the rest of their natural life. 

I don't just mean that they should be banned working in ans academic or industrial programs related to chemistry.  I mean that they should be banned from any work with chemicals at all, up to and including working as a pastry chef.